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Acamprosate in the Treatment Of Binge Eating Disorder: A Placebo-controlled Trial: International Journal of Eating Disorders; Volume 44, Issue 1

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About the Course:

Objective: To assess preliminarily the effectiveness of acamprosate in binge eating disorder (BED).
Method: In this 10-week, randomized, placebo-controlled, flexible dose trial, 40 outpatients with BED received acamprosate (N = 20) or placebo (N=20). The primary outcome measure was binge eating episode frequency.
Results: While acamprosate was not associated with a significantly greater rate of reduction in binge eating episode frequency or any other measure in the primary longitudinal analysis, in the endpoint analysis it was associated with statistically significant improvements in binge day frequency and measures of obsessive- compulsiveness of binge eating, food craving, and quality of life. Among completers, weight and BMI decreased slightly in the acamprosate group but increased in the placebo group.
Conclusion: Although acamprosate did not separate from placebo on any outcome variable in the longitudinal analysis, results of the endpoint and completer analyses suggest the drug may have some utility in BED.

This course is based on the reading-based online article, Acamprosate in the Treatment Of Binge Eating Disorder: A Placebo-controlled Trial: International Journal of Eating Disorders; Volume 44, Issue 1 created by Anna L. Guerdjikova, Ph.D., Erin L. Winstanley, Ph.D., Anne M. O’Melia, MD, Nicole Mori, CNP, Jessica McCoy, BA, Paul E. Keck Jr., MD, James I. Hudson, MD,ScD, and Susan L. McElroy, MD

Publication Date:

January 2011

Course Material Authors

Course Material Authors authored the material only, and were not involved in creating this CE course. They are identified here for your own evaluation of the relevancy of the material this course is based on.

Anna L. Guerdjikova, Ph.D.
Erin L. Winstanley, Ph.D.
Anne M. O'Melia, MD
Nicole Mori, CNP
Jessica McCoy, BA
Paul E. Keck Jr., MD
James I. Hudson, MD,ScD
Susan L. McElroy, MD
The authors of this journal article are a from the Lindner Center of HOPE in, Mason Ohio and the University of Cincinnati College of Medicine in Cincinnati Ohio. Additionally, contributing author James L. Hudson is from the Department of Psychiatry, Harvard Medical School and McLean Hospital in Belmont Massachusetts.

Course Creator

Recommended For:

This course is recommended for Counselors, Psychologists, Social Workers and other mental health professionals who seek knowledge about the pharmacotherapy of binge eating disorder (BED).

Course Objectives:

After taking this course, you should be able to:

  1. Describe the rationale for testing acamprosate, a glutamate receptor modulator, in the treatment of binge eating disorder.
  2. Assess the major findings of the study.
  3. Identify the limitations of the study.


Disclosure of Relevant Financial Relationships

Disclosure of Relevant Financial Relationships

CE Learning Systems, LLC is an independent provider of continuing medical education. CE Learning Systems, LLC has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

In accordance with our disclosure policies, CE Learning Systems, LLC is committed to ensuring balance, independence, objectivity, and scientific rigor for all accredited continuing education. These policies include assigning relevance to, and mitigating, all perceived or real conflicts of interest between any individual with control over the content and any ineligible company (commercial interest).

Any individual with control over accredited content, including planner, faculty, and reviewer, is required to globally disclose:

  1. Individual relationship(s) or lack thereof, and its nature, with any/all ineligible company, and
  2. any investigational, off-label, or non-FDA approved content or discussion

CE Learning Systems, LLC has reviewed these disclosures, assigned relevance based on the relationship and scope of content, and identified those with the potential to compromise the goals and educational integrity of the education. Relevant relationships, or lack thereof, are shared with the learner.

Education has been independently peer-reviewed to validate content, mitigate identified conflicts of interest, and ensure:

  1. All recommendations involving clinical medicine is based on evidence that is accepted within the medical profession as adequate justification for their indications and contraindications in the care of patients.
  2. All scientific research referred to, reported, or used in accredited continuing education in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection, and analysis.
  3. Content is appropriate, fair and balanced, unbiased, referenced, and non-promotional.

The planners have reported the following: There are no relevant disclosures.

Course Material Authors

The authors have disclosed any disclosures within the material.

Course Creator: Tyler Gibson
There are no relevant disclosures.
Commercial support

There is no commercial support for this distance-learning course.

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Course Number 101775
1 CE credit hour
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  • Reading-Based Online
Exam Fee $5.97
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