Skip to main content

A Randomized, Placebo-controlled Crossover Trial in Patients With Binge-eating Disorder and Bulimia Nervosa

To help ensure your CEs are relevant to your practice, we regularly retire courses that are no longer current. This course has been retired. It is no longer available.

We add new courses all the time. Try these categories:

About the Course

To date, only two medications have been approved by the Food and Drug Administration (FDA) for eating disorders: lisdexamfetamine for binge-eating disorder (BED) and fluoxetine for bulimia nervosa (BN). While these two drugs are effective, what are options for patients who cannot tolerate these medications or do not find them helpful? This article describes the results of the first study to rigorously investigate a promising new treatment option for BED and BN: phentermine-topiramate extended release (PHEN/TPM-ER). In addition to helping readers make sense of the study’s major findings, this article will also explain the rationale behind this dual combination drugs including potential mechanisms of action. Finally, this article will help readers stay up-to-date on the latest treatment options for patients who do not have optimal responses to existing FDA-approved medications.

This course is based on the article, A randomized, placebo-controlled crossover trial in patients with binge-eating disorder and bulimia nervosa created by Debra L. Safer MD, et al. in 2019.

Publication Date:

International Journal of Eating Disorders November 23, 2019

Course Material Authors

Course Material Authors authored the material only, and were not involved in creating this CE course. They are identified here for your own evaluation of the relevancy of the material this course is based on.

Debra L. Safer MD

Dr. Debra L. Safer specializes in the treatment of eating and weight disorders. She has practiced psychiatry for more than 15 years. Dr. Safer is the Co-Director of the Stanford Adult Eating and Weight Disorders Program. Her research and clinical work in eating disorders and obesity focus on improving patient outcomes by developing and conducting clinical intervention trials to establish evidence-based treatments. She has co-authored multiple peer-reviewed articles, books, and book chapters, and presented her work both nationally and internationally.

Sarah Adler PsyD

Dr. Adler is passionate about the intersection between behavioral health and technology to increase access to care. She is currently an attending Psychologist in the Eating Disorder and Weight Control Clinic and specializes in both research and clinical care for patients with disordered eating behaviors. Dr. Adler is the Author of The DBT Solution for Binge and Emotional Eating, which was originally written and tested for her doctoral dissertation. Dr. Adler currently teaches and supervises students and post-doctoral fellows in evidence based treatments.

Shebani Sethi MD, MS

Dr. Sethi is an Attending Psychiatrist in the Department of Psychiatry and Behavioral Sciences and Director of Metabolic Psychiatry. She has specialized training and expertise in obesity medicine and adult eating disorders. Dr. Sethi's approach to psychiatric treatment incorporates principles of obesity medicine, metabolic health, and nutrition. She is a co-investigator on a clinical trial testing an FDA approved obesity medication for binge-eating disorder and bulimia nervosa at Stanford University funded by SPARK.

Course Creator

Sandi Cardaman

Sandi Cardaman has been a Licensed Mental Health Counselor for more than 15 years. She has worked with eating disorders, domestic violence and clients who are working with the dependency system.

Recommended For:

Counselors, marriage and family therapists, psychologists and social workers. This course is appropriate for intermediate levels of knowledge. The content is at an intermediate level.

Course Objectives:

After taking this course, you should be able to:

  1. Explain the rationale for repurposing phentermine-topiramate extended release (PHEN/TPM-ER) for treating individuals with binge eating disorder and bulimia nervosa
  2. Describe the effects on binge eating and other key outcomes when PHEN/TPM-ER was compared to placebo in a randomized crossover study.
  3. Identify future research directions to follow-up on these preliminary positive findings regarding the safety and efficacious use of PHEN/TPM-ER for binge eating disorder and bulimia nervosa

Disclosure to Learners

Disclosure of Relevant Financial Relationships

CE Learning Systems adheres to the ACCME's Standards for Integrity and Independence in Accredited Continuing Medical Education. Any individuals in a position to control the content of a CE activity – including faculty, planners, reviewers, or others ― are required to disclose all relevant financial relationships with ineligible entities (formerly known as commercial interests).

The following relevant financial relationships have been disclosed by this activity's planners, faculty, and the reviewer:

Planners and Reviewers

The planners of this activity have reported that they have no relevant financial relationships.

Commercial support

There is no commercial support for this distance-learning course.

Exam Questions

All exam questions for the course are visible on this page for members of

Membership is free, and you can register today! You'll only pay when you're ready to purchase a course, or if you take advantage of the Unlimited Package.

If you're already a member, please sign in to see the exam questions for this and all other courses.

Discuss this course

You can share your thoughts about this course after you pass the exam.

Sign In or Register to get started.


  • Is this course approved for my continuing education requirements?

    Yes, most likely. Look Up Your State Board for more detailed information. Logged-in site members will see the relevant approval information displayed in the Approvals tab for every course.

  • Do you have accommodations for my disability (ADA)?

    If you are having trouble using, please contact us! We would be happy to accommodate your needs right away, and your input will help us make more accessible for future users too.

  • How do I enroll in this course?

    Use the Enroll In This Course button and just follow the instructions! You don't pay anything until you're ready to take an exam.

  • What do I have to do to complete the course?

    To complete the course, review the course objectives, then review the material, and then pass the exam with a score of 75% or greater and lastly complete an evaluation.

  • How do I access the materials?

    Most of our courses are based on online articles available for free to the public. Some courses, such as those based on books, require that you purchase the material. Use the Materials tab above for more info. You don't need to enroll in the course to access materials, whether free or paid. So you always know what you're getting into before you commit to taking the exam.

  • How do I get my certificate?

    Your certificate(s) will be available to download or email immediately when you pass the course exam and complete the evaluation.

  • Can I contact you for more help?

    Yes! Use the Help widget at the bottom-right of the screen anywhere on to search our help docs, or to ask our support team for help. Unlike most of our competitors, has live US-based support reps to help you by email, chat, or phone.

Course Retired
Course Number 102721
1 CE credit hour
Sign in for credit hours relevant to your credentials.

  • Reading-Based Online
Exam Fee $5.97
There's no exam fee with an Unlimited CE membership! Read More

No Cost Materials

24 members have taken this course

Try a free CE course.

Get started by trying a free course of your choice. No payment info required!

Sign Up Free

View all free trial courses

Happy therapist using